Sanderson, J. T., Slobbe, L., Lansbergen, G. W., Safe, S., and van den Berg, M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Kandala, P. K. and Srivastava, S. K. Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Estrogen Dominance Detox Diet: The 21 Foods To Reverse It Naturally Research indicates that dietary intake of lignans such as 7-hydroxymatairesinol (HMR), and healthy serum enterolactone levels provide support for cellular, heart, breast, bone and cognitive health. Heavy periods Painful periods Bloating before your period Difficulty with weight gain on your hips, butt, or thighs Fibroids Endometriosis Adenomyosis Perimenopause Menopause Hair loss, or hair popping up where you don't want it What Does DIM Do For Hormones? View abstract. It is not intended to diagnose, treat, cure, or prevent any health problem-nor is it intended to replace the advice of a physician. View abstract. Case Rep Med. Detox Headache: Causes, Symptoms & Natural Remedies - Healthline J Steroid Biochem Mol Biol. Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. These are the symptoms of dextromethorphan withdrawal, and depending on someones use habits, they may range from a little uncomfortable, to potentially life-threatening. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. 6-1-2009;107(3):516-527. Bad estrogen can pack on the pounds, especially around your hips and buttocks. View abstract. Cancer Epidemiol.Biomarkers Prev. 5-1-2006;66(9):4880-4887. J.Cell Biochem. Dextromethorphan Withdrawal Timeline, Symptoms, Effects - Detox Local Thats because the underlying cause of the symptoms is radical hormone fluctuations. The data suggested that DIM enhanced estrogen metabolism and could potentially reduce the risk of developing thyroid cancer by decreasing estrogen levels[R]. Phillippe Greenough. View abstract. View abstract. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. We list many common conditions you might want to take a DIM supplement for, and tell you how long it may take to work for each, and how clear the guidance is as yet on its effectiveness for those conditions. Until more is known about the safety of diindolylmethane, children and pregnant or nursing women should not take DIM supplements. Made for the elite athlete and the strong-willed our products were designed to fuel your athletic performance. The statements made regarding some or all products have not been evaluated by the Food and Drug Administration. Gong, Y., Sohn, H., Xue, L., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells. 2006;19(3):436-442. By the fourth week, someone may be close to their usual selves again. 3,3'-Diindolylmethane and genistein decrease the adverse effects of estrogen in LNCaP and PC-3 prostate cancer cells. View abstract. This requires effective psychiatric and therapeutic care if dangerous outcomes are to be avoided. Because of this, we cannot say how long it would take to work, but we know that using DIM under a doctors supervision can do more good than harm for most women. Hear t disease. Drinking plenty of water and getting enough fiber through whole foods can help the body push toxins out of the body. Learn how to log information about your pain levels, potential triggers. Mol.Pharmacol. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. italica) Sprout Std. 3-1-2010;79(5):715-721. Contact Evexias Denver Medical Centers and make an appointment today! Smith, T. K., Lund, E. K., Clarke, R. G., Bennett, R. N., and Johnson, I. T. Effects of Brussels sprout juice on the cell cycle and adhesion of human colorectal carcinoma cells (HT29) in vitro. DIM supports the expression of antioxidant and phase II detoxifying enzymes, which protect tissues from oxidative stress, toxins and reactive substances. Biochem Pharmacol. Ishikawa T, Glidewell-kenney C, Jameson JL. Safe supplemental dosages have not been established; in fact, dosages of DIM may prove tricky to determine. Some people may see noticeable results in four days, and for others, it may take 30 days or more. 2003;41(6):745-752. Progesterone in particular plays a crucial role in sleep quality, Protea Nutrition was built upon the foundation of creating naturally based supplements that help improve the customers health on a cellular level. Chang, X., Tou, J. C., Hong, C., Kim, H. A., Riby, J. E., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Available at: https://ntp-server.niehs.nih.gov. View abstract. These glutamate interactions, among other somewhat mysterious mechanisms, is one of the ways it acts as a cough suppressant. Turnips. View abstract. To get enough DIM through food, one would have to eat at least 2 lbs. Ltd. Its allergy season, so at TMC were focused on how to keep your histamine down and your mast cells in check. These include: Weight gain Bloating Acne Headaches Worsened PMS symptoms Emotional disturbances ( depression, anxiety, mood swings) When androgens and (aka male hormones) and hormone receptors bind, changes in your skin can occur, which lead to acne. People who use DIM supplement as a part of their weight loss program can realistically expect to see results within six weeks to six months. DIM works to prevent the bad estrogen pathways and promote a balance of good estrogen and testosterone, to keep your skin clean and clear. This may result in: Along with headaches, other symptoms during a detox diet may include: When reading about these detoxes, the symptoms may be called various names including healing reactions, cleansing reactions, detox symptoms, and healing crises. These symptoms can include, headaches, irritability, body aches, flulike symptoms, changes in bowel movements (most commonly diarrhea), fatigue and insomnia. Limit consumption of refined sugar, table salt and saturated fats as these increase stress on the liver. 2002;132(11):3314-3324. Unlike many other substance use disorders, your body needs sugar. DIM - Side effects? Detoxing symptoms? : r/Supplements - Reddit By the beginning of the second week, most of the physical symptoms may still be present, but they will be on their way to resolution. Yerushalmi R, Bargil S, Bar Y, et al. Also, if using topically, be sure to check if youre allergic by placing a test patch of oil on your skin and seeing if you have a reaction. Smith, S., Sepkovic, D., Bradlow, H. L., and Auborn, K. J. If you choose to stop taking DIM supplements, you do not need to wean yourself off of it. While these events may have some benefits, they wildly oversimplify the concept of detoxification. J.Nutr. Inflammation slows this transport process down and can make phase 3 estrogen detox slow leading to unwanted excess estrogen symptoms (mood swings, breast tenderness, painful, heavy periods, etc.) Female sex hormones including estrogen and progesterone help conduct our sleep cycle and overall mood. RELATED ATICLE How To Get Better Quality Sleep. After its over you usually feel better like Any detox. BioResponse DIM provides 25 mg per serving of a highly absorbable form of diindolylmethane, an important metabolite of indole-3-carbinol. For example, DIM works on phase I liver detoxification, while calcium D-glucarate works on phase II and elimination through the bowels (what some call phase 3). However, consulting with a physician who specializes in hormone imbalance and is open to combing BHRT with alternative supplements like DIM can get you started. Symptoms of estrogen dominance range from stubborn belly fat and weight gain, to chronic fatigue, thinning hair, bloating, depression, low libido, acne, and infertility. Dehydration can cause headaches. Diindolylmethane might have effects similar to estrogen. Some people may even stop the use of these helpful natural substances before their body has a chance to fully rid itself of the toxins due to these detox symptoms. We believe thateveryone can optimize not only their athleticperformancebut their human potential. These neurotransmitter systems will undergo an opposite but similar process of downregulation where the brain reduces the sensitivity of their receptors. These symptoms will begin fairly soon after the last time someone uses dextromethorphan and commonly persist at fairly intense levels for at least a week. Parkin, D. R. and Malejka-Giganti, D. Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3'-diindolylmethane and its parent compound indole-3-carbinol. Stroke. Get the latest on fitness, nutrition, and wellness every week, Get exclusive access to discounts and the latest onfitness, nutrition, and wellness delivered straight to your inbox, Free shipping on domestic orders over $99, Join our email list and receive member-exclusive promos, We're committed to an amazing customer experience, Your payment information is encrypted and never compromised. You can learn more about how we ensure our content is accurate and current by reading our. 127,8 (2010): 1748-57. Nearly 13 percent of the women reported changes in their menstrual cycle when they took DIM. Allergies arent the only problem caused by overactive mast cells. The Benefits of Calcium D-Glucarate - Dr. Jolene Brighten RELATED ARTICLE How To Effectively Reduce Your Stress. "Detox Symptoms" There is no research supporting the existence of "detox symptoms" with calcium-D-glucarate. Am.J.Pathol. Ann N Y Acad Sci 1999;889:204-13. Instead, it boosts your bodys capacity to metabolize estrogen, so your lifestyle choices (diet, exercise, etc.) Increased estrogen canalsobe caused by poor sleep habits, which inhibit the production of melatonin, a hormone that can also protect against estrogen dominance[R]. It appears to help destroy cancer cells and reduce swelling. Commonly, they start with fasting no food or drink. The bottom line is that DIM may cause hormonal disturbances, reports NYU Langone Medical Center. Bad estrogen metabolites have been found to cause cancer and are made prevalent by obesity and man-made environmental chemicals known as free radicals. View abstract. J.Nutr. of cabbage, Brussels sprouts, or kale a daywhich is pretty . RELATED ARTICLE How To Get Skinny Overnight. [3,3-diindolylmethane enhances the inhibitory effect of idarubicin on the growth of human prostate cancer cells]. View abstract. Who here has tried DIM (diindolylmethane) supplement? Read on to find out how to balance your hormones and forget about hormonal imbalance symptoms! J.Nutr. 2012 Jan 3;106(1):45-52. This is often a subjective intensification since as the physical symptoms resolve, they are no longer able to distract from the psychological symptoms, therefore they may seem more intense. However, it's recommended to get at least 100 mg of DIM each day in order to see results while a typical diet only supplies 2-24 mg of DIM daily. The health industry has taken hold of this concept and popularized it into various forms, including juice cleanses, fasting and other weight loss gimmicks. BRCA1 mRNA levels following a 4-6-week intervention with oral 3,3'-diindolylmethane. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. 2023 DailyBenefit.com However, DIM doesnt burn fat. Calls to any sponsored hotline (non-facility) will be answered by: If you wish to contact a specific medical detox center then find a specific detox center using our detox locator tool. These statements and testimonials are not intended to diagnose, treat, cure or prevent any disease. Cancer Lett 2000;151:169-79. The symptoms of dextromethorphan withdrawal can also vary in both intensity and duration, sometimes substantially, between different people. View abstract. If this becomes a problem, talk to your doctor. 635-640. If you have liver or kidney disease, or are at a higher risk for estrogen-sensitive cancers or hormone-related conditions, consult your physician before taking DIM. Some herbs suggested for natural headache relief include: Advocates of natural healing feel that meditation will help with detox headaches by relaxing your central nervous system, increasing oxygen supply to your brain, and reducing stress. Taking a probiotic and consuming gut friendly foods such as kefir, yogurt, kimchi, and sauerkraut supports the gut and ensures and efficient detox pathway. Nearly 13 percent of the women reported changes in their menstrual cycle when they took DIM(R). Do detox diets offer any health benefits? Dextromethorphan, even though it is derived from morphine, does not have appreciable interactions with opioid receptors. 2008;25(9):2117-2124. If youre thinking about using DIM to diminish hormonal acne, then youve probably already knocked out the list of quick-fix potions and spot treatments that dont really deliver. In particular, people of northern European ancestry may have genetic factors that can increase this half-life to around 30 hours, so in these individuals, the withdrawal timeline will be significantly longer, although this also means that the symptoms of dextromethorphan withdrawal will be less intense. This is also why when starting Baseline+, it is recommended to ease into the dosage starting at 1 capsule and increasing every 5 days until the recommended dosage is achieved. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Then they progress to a strict diet of water, fresh fruit and vegetable juices, and raw fruits and vegetables. 1978;38(5):1410-1413. View abstract. Alternatives to finding addiction treatment or learning about substance abuse: To learn more about how Detox Local operates, please contact us, All submissions we receive will be followed up diligently and validated by a Detox Local staff member. Through long-term and heavy use of dextromethorphan, the systems that were affected will undergo changes. Home Withdrawal Timelines Dextromethorphan, Medically Reviewed By: These are strictly psychological in nature, but they can still be present significant challenges to someones continued sobriety and health. DIM & Detox offers support for antioxidant defence and function of the liver, an organ essential to the bodys detoxification. Detox headaches are often caused by your bodys reaction to missing an item, such as sugar or caffeine, that was habitually present. DIM may lead to positive -- or negative -- effects on various types of hormone-sensitive cancers. Mustard Greens. 2008;17(10):2619-2624. Vivar, O. I., Lin, C. L., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status. Kim, E. J., Park, S. Y., Shin, H. K., Kwon, D. Y., Surh, Y. J., and Park, J. H. Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. What Are DIM Supplements and Are They Worth Taking? Add to Cart. Last medically reviewed on July 17, 2018. We cover what to expect with lumbar puncture (spinal) headaches, including how long they last and how to treat them. You may have shorter menstrual cycles, lengthier periods, or two monthly periods. OR submit you number and someone will call you shortly! Both medication and clinical therapy can be very effective at reducing the risks and the severity of these symptoms. If you want to learn more about what DIM is and how it works, do check out one of our previous posts on DIM. Find out for yourself! Benjamin Caleb Williams RN, BA, CEN, Written By: Taking large amounts of diindolylmethane might interfere with hormone replacement therapy. Mol.Endocrinol. View abstract. Vermillion Maier ML, Siddens LK, Uesugi SL, et al. We have more in-depth withdrawal guides for drugs such as: Disclaimer: The information provided on DetoxLocal.com is intended for educational purposes and is not a substitute for professional medical treatment. One type of detox, a detoxification diet, is designed to eliminate toxins from your body. The symptoms of dextromethorphan withdrawal can sometimes be quite intense and may be dangerous in some circumstances, although this is very rare. Check the article to learn more about the mast cell. Find out about home remedies to ease. Glutamate is a major excitatory neurotransmitter in the brain that has a multitude of roles, and the fact that dextromethorphan acts as an antagonist at NMDA glutamate receptors means that it can reduce the excitatory impact produced by glutamate. Best.Pract.Res.Clin.Obstet.Gynaecol. How To Support Estrogen Detox | Hormone Healing RD B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. 2008;138(1):17-23. About one-fourth of the women experienced an increase in bowel frequency, while 18 percent had headaches or gas. While they are less intense than the acute symptoms, they often fade gradually over time. 1-15-2010;70(2):646-654. 7-20-2007;282(29):21542-21550. Since DIM affects how a womans body produces estrogen metabolites, it can be an effective addition to a hormone replacement treatment plan. Pharm.Res. When 353 women at risk for developing cervical cancer took DIM supplements, nearly 70 percent experienced some type of nonserious side effect, according to a study published in the "British Journal of Cancer" in November 2011. View abstract. B. and Ichikawa, H. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Jellinck, P. H., Makin, H. L., Sepkovic, D. W., and Bradlow, H. L. Influence of indole carbinols and growth hormone on the metabolism of 4-androstenedione by rat liver microsomes. Even though they do not pose direct, physical risks, deep depression can lead to thoughts of suicide, and even suicide attempts. An enzyme called aromatase, which we all have, converts a portion of our testosterone into estrogen. Accepted file types: pdf, doc, docx, odt, rtf, Max. When DIM is used as a supplement for menopause support, your doctor will get you started at the lowest dose. Less common side effects included nausea, diarrhea, vomiting and a skin rash. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. The estrogen metabolites produced by DIM bind to specific proteins that can help improve hormonal imbalances. DIM Supplements: Benefits, Side Effects, and Dosage - Healthline When To Take Dim Supplement? - Health Articl We provide the nutrients you need to power your active lifestyle. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent. Weperformwhen you perform. Biochem Pharmacol 1996;51:1069-76. 8 Tips to Ease Detox Discomfort - Dr. Mark Hyman 2006;69(2):430-439. Your body is unique. All rights reserved. View abstract. Carcinogenesis 2002;23(8):1297-1305. Drug Metab Dispos 2021;49(8):694-705. 3'3-diindolylmethane induces apoptosis in human cancer cells. The most common of these symptoms are hot flashes night sweats weight gain mood swings memory problems difficulty concentrating insomnia Regulating estrogens is the key to supporting menopausal symptom relief. Azmi, A. S., Ahmad, A., Banerjee, S., Rangnekar, V. M., Mohammad, R. M., and Sarkar, F. H. Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM). Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5 alpha-reductase inhibitor. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. 2006;169(5):1833-1842. Oncogene 3-31-2005;24(14):2343-2353. J Pharmacokinet Pharmacodyn. We never want, Privacy | Terms | Returns | Blog | Contact Us. The recipe of Sauted Zucchini is not only detox friendly, but also easy to make. This could change the effects and side effects of these medications. Aggarwal, B. 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. DIM converts estrogen and reduces its effect. It has its own timing when it comes to absorbing supplements. View abstract. View abstract. Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Biochem.Biophys.Res.Commun. For some women, it may take six months to see optimal results. View abstract. Four . 6 (Nov., 2000), pp. Varicose Veins Risks: How to Avoid Blood Clots, Exclusive promos and specials on our services, Important announcements and treatment offerings. DIM Detox: What is it? - Protea Nutrition View abstract. DIM may interact with medications, so avoid supplements if you take prescription medications. Chang, Y. C., Riby, J., Chang, G. H., Peng, B. C., Firestone, G., and Bjeldanes, L. F. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, a major in vivo product of dietary indole-3-carbinol. Diindolylmethane | Memorial Sloan Kettering Cancer Center exhibit decreased levels of progesterone. Dextromethorphan, also known as DXM, is a common ingredient in cough medications such as Robitussin, and until recently, there were no regulations regarding the sale of dextromethorphan in America. But something that helps take away the side effects of DIM is Calcium-D-Glucarate. Headache diaries keep track of the number and types of headaches you have. Fatty liver disease. The way we believe we can optimize performance is through. Castaon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. The reason is that to provide the best results DIM takes time to detox your liver and convert your hormones. One day your estrogen levels may be normal. Thats because women with PCOS have high levels of androgens. While DIM can be obtained naturally by eating tons cruciferous veggies its not realistic to achieve the benefits of these foodswithoutsupplementation. Silymarin, alpha lipoic acid and n-acetyl-l-cysteine act to support phase II detoxification enzyme activity in the liver and offer antioxidant support for cellular protection. View abstract. Androgens are considered male sex hormones because they give men their masculine features. B., Ma, L., Byon, C. H., and McDonald, J. M. Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein. View abstract. You are undoubtedly familiar with the term, detox. About one-fourth of the women experienced an increase in bowel frequency, while 18 percent had headaches or gas. Kim, E. J., Park, H., Kim, J., and Park, J. H. 3,3'-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators. BioResponse DIMprovides 25 mg per serving of a highly absorbable form of DIM, an important metabolite of indole-3-carbinol. View abstract. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. Pharmacokinetics and pharmacodynamics of 3,3'-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes. View abstract. Some users have complained of hormone-related problems resulting from supplementation. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Mol.Cancer Ther. View abstract. Chronic Inflammation. In fact, many of the people that have the most significant gains from DIM will experience headaches or fatigue in the first few days. The contents of thisblogshould not be taken as medical advice. Glucosinolates in broccoli, including indole-3-carbinol and sulforaphane, help support healthy detoxification. DIM Supplement: How Long Does it Take to Work? Estrogen- and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoidGenes and environment: the official journal of the Japanese Environmental Mutagen Societyvol. I had symptoms like night sweats, PMS, weight gain and hormonal migraine (before ovulation and period). View abstract. 2015 Aug;42(4):401-8. The study demonstrated that chlorophyllin supplementation protected the liver from oxidative damage and improved liver enzyme levels, suggesting its potential to support liver detoxification. Riby, J. E., Xue, L., Chatterji, U., Bjeldanes, E. L., Firestone, G. L., and Bjeldanes, L. F. Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells. You will need to take DIM daily for at least 30 days before deciding if it works for you. Detox symptoms should only last three to seven days. According to the U.S. National Institutes of Health, there isnt any convincing evidence that self-managed detox diets or cleansing programs actually remove toxins from your body or improve your health. ~HB Support. View abstract. However, forecasting how long it will take for DIM to work on menopausal symptoms is tricky. Alcohol withdrawal delirium (AWD) is the most serious form of alcohol withdrawal. Some herbal teas to consider are: Since essential oils arent regulated by U.S. Food and Drug Administration, be sure to buy oils from reputable sources. 2010;116(3):464-467. 2008;7(6):1708-1719. How To Break Your Sugar Addiction - Cleveland Clinic Why? $ 48.00. Zhao, Y. Y., Zhou, L., Pan, Y. 2007;137(1):31-36. One pilot study gave patients with estrogen dominance 300mg of DIM every day for . Hong, C., Firestone, G. L., and Bjeldanes, L. F. Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. Carcinogenesis. Some of the post-acute symptoms of dextromethorphan withdrawal include: These symptoms have been known to persist for weeks, months, or rarely even years after the last time someone used dextromethorphan. The psychological symptoms, however, may seem more intense. As for how long it will take for DIM to reverse the effects of high androgens and get good estrogen back into balance, thats unknown. The good news is that following an estrogen detox diet can help balance out your hormone levels and reverse estrogen dominance naturally and safely. With serotonin and norepinephrine, receptors were experiencing more stimulation due to dextromethorphans inhibition of their reuptake transporters. Alpha lipoic acid and N-acetyl-L-cysteine (NAC) also provide antioxidants for cellular protection and act to support phase II detoxification enzyme activity in the liver. So, the benefits of taking DIM are so many, that every woman can benefit from it. Ali, S., Banerjee, S., Ahmad, A., El-Rayes, B. F., Philip, P. A., and Sarkar, F. H. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. 2004;18(2):291-302. 2696 S. Colorado Blvd. how long should you take DIM supplements? 2006;17(10):659-664. Seven Natural Ways Chlorophyll Can Ease Women's Digestive - Medium